In order to achieve more competitive advantages and enhance their innovation capacity, SMEs and Industries can have access to the following internal laboratories and facilities:




SISSA MathLab is a laboratory for mathematical modeling and scientific computing devoted to the interactions between mathematics and its applications, powered by the interest in problems coming from the real world, from industrial applications and from complex systems. A proven value partner for companies interested in mathematics as a tool for innovation offering a research team that focus on new trend in computational mechanics and numerical analysis.

Referent: Prof. Gianluigi Rozza


Laboratory of Prion Biology

The focus of the Prion Biology Laboratory is studying prion diseases, rare and fatal neurodegenerative maladies that affect humans and animals for which there is no diagnostic tool, nor a cure. The main research lines of the lab are: PrPC Function, Structural Biology of PrPC, Transcriptomics, Prion-like Diseases and Theranostics.

Referent: Prof. Giuseppe Legname


Molecular and Statistical Biophysics Group 

Focused on the development and application of theoretical and computational approaches to characterize the properties of biomolecular systems. Most of the research activity is devoted to characterize the kinetics, thermodynamics and mechanics of proteins and nucleic acids and to seek quantitative comparison with experimental data. Its main goals are:  
(i) addressing relevant problems in biological physics posed by the unprecedented wealth of detailed experimental data that is nowadays available and  
(ii) allowing for the most stringent validation of the methods and models that we develop to extend the current reach of computational studies of biomolecules.

Referents: Prof. Alessandro Laio | Prof. Guido Sanguinetti | Prof. Giovanni Bussi | Prof. Cristian Micheletti


Laboratory of Computational Genomic

The Computational Genomic Lab focuses in particular on the development and usage of bioinformatics pipelines, data integration and harmonization, tools, methods and databases for large-scale functional genomics data analysis.

Referent: Prof. Remo Sanges


Laboratory of Neural Dynamics

SISSA Laboratory of Naural Dynamics focused on quantifying information processing and the response properties of cortical neurons, investigating the impact of synaptic "noise" and ion channels "noise", developing mathematical models of neurons and neuronal networks and investigating heterogeneities in human and rodent cortical microcircuits.

Referent: Prof. Michele Giugliano 


Theoretical and Scientific Data Science Group

The group focuses on machine learning methodologies to understand biology and disease; theories of learning artificial and biological neural networks; custom-made machine learning solutions from the cutting-edge in the field as well as development of beyond-the-state-of-the-art methods to deal with the hardest, most intractable problems; statistical tools to tackle any data-driven statistical problem, from inference to optimization, from model comparison to anomaly detection.

Referents: Prof. Alessandro Laio | Prof. Guido Sanguinetti | Prof. Roberto Trotta


Neurobiology Group

Such laboratories offer advanced tools for physiological research, DNA sequence analyzer, and molecular biology instrumentation. This Area also uses advanced computers and software for molecular modeling, and for the study of hybrid bio-electronic devices. Advanced types of software for the study of biology-inspired machine vision are in use. The microscope facilities of the Neurobiology Area are: an electron microscope, two confocal microscopes and numerous fluorescence microscopes. Its studies concerns also nanomaterials (carbon nanotubes and graphene based nanomaterials) applied to neurons.

Referent: Prof. Laura Ballerini


Neurobiology Group - Heppenstall Group

The Heppenstall group develops molecular, imaging and electrophysiological techniques to address how neurons in the skin detect and convey information about pain, itch and touch to the brain and understand how sensory neurons give rise to our sense of touch.

Referent: Prof. Paul Heppenstall


Laboratory of Cerebral Cortex Development 

Centre of excellence interested in molecular mechanisms specifying embryonic cortico-cerebral precursors and regulating their proliferation-differentiation profile. Their work is mainly focussed on a small set of evolutionarily conserved transcription factor genes involved in these processes. They are dissecting their impact on the behaviour of cortico-cerebral neural stem cells and committed progenitors, in normal development and select neurodevelopmental disorders. Moreover they are working at ncRNA-based methodologies, aimed at stimulating transcription of endogenous genes for therapy of haploinsufficiencies.

Referent: Prof. Antonello Mallamaci


Laboratory of Neural Computation 

This Lab is interested in the computational principles that underlie the ability of the animal brain to perform efficient inference and prediction under tight resource constraints:
• study behavior and cognition in animals and humans, and information processing in neuronal circuits; 
• develop and employ techniques that draw from a broad range of approaches, including statistical learning, information theory, artificial neural networks, and Bayesian statisticss.

Referent: Prof. Eugenio Piasini



The new Advanced Mechatronics Laboratory, Lama FVG, opened in Friuli Venezia Giulia, as result of the collaboration between  the Universities of Trieste and Udine and the International School for Advanced Studies (SISSA) and was funded by the Ministry of Education, University and Research (MIUR) and Regione Friuli Venezia Giulia. The Lama FVG is a centre of excellence for industrial innovation and cutting-edge research in frontier technology sectors, dedicated to technological development, advanced training on the basis of a new synergy between academia and industry. Thanks to the important technological equipment, the laboratory aims to become a centre of excellence for 3D printing of metal objects, advanced robotics and the digital transformation of production systems in the Alpe-Adria Region.


High Performing Computing Laboratory 

SISSA (with ICTP) host one of the largest HPC facilities in Italy, a cluster with more than 4000 cores based on the newest technology. This allows scientists, SMEs and Industries to gain direct experience in a production environment and to explore characteristics and configurations of an HPC cluster. The HPC system also provides a number of nodes with accelerators explicitly dedicated to advanced research and industry projects. The in-house facilities are complemented by state-of-the-art facilities available world wide to computational research groups involved with the MHPC. Experimental HPC facilities are also available trough european research program which involves local scientific research institution and companies.


Cognitive Neuroscience Laboratories

Such laboratories include test cabins for psycholinguistic experiments with adults and children using sophisticated artificial speech; a virtual theatre for presenting visual scenes to test reasoning processes in children; high-density evoked potential recording to carry out neuroimaging on children and adults; a neuropsychology laboratory equipped for transcranical magnetic stimulation. Other methodological highpoints include the tactile perception laboratory, which examines the neuronal basis of sensation using a 100-microelectrode matrix implanted in cerebral cortex; this group also monitors neuronal activity underlying perceptual decisions in behaving animals.